Polynucleotides Explained: A Beginner’s Guide to Regenerative Aesthetics

Discover the potential of polynucleotides in regenerative aesthetics. Learn how they work, their benefits, and what to consider before treatment.

NexGen Clinic Editorial TeamReviewed by the NexGen Clinic team 3 min readPublished 7 July 2026
Polynucleotides Explained: A Beginner’s Guide to Regenerative Aesthetics

Key takeaways

  • Polynucleotides are used in regenerative aesthetics for skin rejuvenation.
  • They may help improve hydration and skin texture.
  • Consultations are essential for personalised treatment planning.
  • Aftercare is critical for optimal results.
  • Comparisons with Profhilo highlight different benefits.
In this article
  1. Understanding Polynucleotides
  2. What to Expect from Polynucleotide Treatments
  3. The Treatment Procedure
  4. Comparison: Polynucleotides vs Profhilo
  5. Who This May Suit
  6. Who May Not Be Suitable
  7. What to Ask Before Treatment
  8. Aftercare Considerations
  9. When to Book a Consultation

Understanding Polynucleotides

Polynucleotides have emerged as a noteworthy component in the realm of regenerative aesthetics. At their core, polynucleotides are macromolecules made up of nucleotide sequences, which form the building blocks of DNA and RNA. In aesthetic applications, they are primarily used to promote skin rejuvenation and hydration.

In recent years, polynucleotides have become increasingly popular in procedures designed to support skin health, offering a potential avenue for enhancing the appearance of fine lines and skin texture. Their unique properties enable them to stimulate cellular processes, making them an appealing option for individuals considering non-surgical aesthetic treatments.

What to Expect from Polynucleotide Treatments

When undergoing polynucleotide treatments, patients may experience revitalisation in skin texture and elasticity. These treatments are typically administered via injections, allowing for precise application directly to areas of concern. The procedure is designed to promote hydration and may support collagen production over time.

The Treatment Procedure

The process generally involves several key steps: consultation, preparation, administration, and aftercare. During your consultation at our NexGen Clinic in Cambridge, a qualified practitioner will assess your needs and discuss desired outcomes. They will prepare a tailored treatment plan for you.

  • Preparation: The skin may be cleaned, and a topical anaesthetic can be applied to enhance comfort during the procedure.
  • Administration: Polynucleotides are injected into targeted areas using fine needles.
  • Aftercare: Post-treatment instructions will guide patients on managing any minor swelling or redness.

Comparison: Polynucleotides vs Profhilo

Both polynucleotides and Profhilo are popular treatment options aimed at skin rejuvenation, yet they offer distinct benefits and mechanisms of action. Here’s a brief comparison:

FeaturePolynucleotidesProfhilo
CompositionNatural nucleotide sequencesHyaluronic acid
ActionPromotes skin regenerationHydration and bio-remodelling
Duration of EffectsEffects may vary based on individual factorsGenerally lasts 6-12 months

Your initial consultation will be an opportunity to discuss which treatment may best suit your needs.

Who This May Suit

Polynucleotide treatments are suitable for a range of individuals seeking to improve skin quality. Those with concerns such as dullness, fine lines, or a loss of elasticity may find benefit from this approach. It can be considered for people of various ages, particularly those starting to notice early signs of skin ageing.

However, it is essential to note that a professional consultation is crucial to determine the appropriateness of polynucleotides for your specific skin type and concerns. Speak to our clinic for personalised guidance.

Who May Not Be Suitable

While many can safely receive polynucleotide treatments, certain factors may contraindicate their use. Individuals with specific skin conditions or those who are pregnant or nursing should discuss their options thoroughly with their practitioner.

What to Ask Before Treatment

Before opting for polynucleotide treatments, preparing a list of questions can ensure a thorough understanding of the procedure. Here are some key inquiries to consider:

  • What are the expected results and effects of the treatment?
  • How long is the recovery period?
  • Are there any potential side effects?
  • How should I prepare for the treatment?
  • What aftercare will be needed?

Your practitioner at NexGen Clinic will be happy to answer these and any other questions you may have, ensuring you're well-informed every step of the way.

Aftercare Considerations

Post-treatment care is critical to achieving optimal results with polynucleotide injections. After your session, avoid significant sun exposure and refrain from wearing makeup for at least 24 hours. Hydrating the skin adequately with moisturisers recommended by your aesthetician can further support the healing process.

Minor swelling or tenderness may be experienced but typically subsides within a few days. Should any unusual symptoms arise, contacting your practitioner for guidance is advised.

When to Book a Consultation

If you are considering polynucleotide treatments and wish to explore how they can support your skin goals, the first step is to book a consultation. Meeting with a skilled practitioner allows for personalised advice and a tailored treatment plan that aligns with your unique skin requirements. This proactive approach ensures that your journey into regenerative aesthetics is informed and comfortable.

Ultimately, polynucleotides can offer an innovative option for those seeking subtle enhancements in their skin quality. At NexGen Clinic, we remain committed to providing meticulously tailored aesthetic treatments designed to nurture your skin gently and effectively.

Curious about regenerative aesthetics?

Book a regenerative aesthetics consultation with NexGen Clinic to find out whether these treatments suit your skin.

Book a Consultation

Frequently asked questions

What are polynucleotides?

Polynucleotides are sequences of nucleotides that may promote skin regeneration in aesthetic treatments. Book a consultation for details.

How do polynucleotides benefit the skin?

They may help promote skin hydration and texture improvement. However, results vary between individuals, so a consultation is essential.

What is the difference between polynucleotides and Profhilo?

Polynucleotides focus on skin regeneration using natural sequences, while Profhilo primarily hydrates with hyaluronic acid. Consult for personalised advice.

Who should consider polynucleotide treatments?

Those seeking to improve skin quality, texture, and elasticity may benefit. A consultation can help determine suitability.

Is aftercare necessary following treatment?

Yes, proper aftercare can enhance results; it’s advised to avoid sun exposure and follow instructions from your practitioner.

How long do results last?

Results may vary; it’s best to discuss expected duration during your consultation with a qualified practitioner.

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